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Genetics of Misophonia Linked to Anxiety and Depression in Adults

Unexpected discoveries: how genes affect sensitivity to sounds

Misophonia may be closely associated with anxiety disorders. A new study has identified genetic overlaps with depression and PTSD. Find out why everyday sounds trigger strong emotional reactions.

Certain sounds can be truly infuriating: the screech of nails on a chalkboard, loud chewing, or even just ordinary breathing. For people with misophonia, these triggers become a real ordeal, provoking not just discomfort but a storm of negative emotions. Recent scientific studies from the Netherlands have shed light on the fact that this sensitivity may be linked not only to psychological traits but also to specific genes associated with anxiety and depression.

Researchers from Universiteit van Amsterdam analyzed extensive genetic databases, including the Psychiatric Genomics Consortium, UK Biobank, and 23andMe. Their findings were unexpected: people who self-identified as having misophonia were more likely to carry genes associated with mental health disorders, as well as tinnitus—a persistent ringing in the ears.

Genetic links

Psychiatrist Dirk Smit and his colleagues found that people with misophonia often have genetic markers typical of anxiety disorders, depression, and post-traumatic stress disorder (PTSD). This may suggest shared neurobiological mechanisms affecting both sound perception and emotional responses.

Interestingly, patients with tinnitus also tend to exhibit more symptoms of anxiety and depression. According to Smith, genes that increase susceptibility to PTSD may also heighten the likelihood of developing misophonia. This finding suggests that therapeutic methods used for PTSD could also be effective for people with misophonia.

Symptoms and Manifestations

However, the presence of similar genetic factors does not mean that the mechanisms behind these conditions are identical. Research shows that people with misophonia are prone to internal stress, feelings of guilt, loneliness, and increased anxiety. Reactions to triggering sounds can range from mild irritation to severe emotional distress that disrupts daily life.

Scientists note that misophonia is not only expressed as anger or irritation but also as feelings of guilt over one’s emotional responses. This distinguishes it from other disorders linked to aggression or impulsivity.

Unexpected Results

An interesting fact: contrary to expectations, misophonia is less common among people with autism spectrum disorders (ASD). Although they often display heightened sensitivity to sounds, genetic data indicate that these two conditions are independent. This suggests that there may be different forms of misophonia influenced not only by biology but also by personality traits.

The authors of the study emphasize that their findings are based primarily on data from European populations, and that the diagnosis of misophonia was determined through self-reports rather than medical assessments. This may affect the accuracy of the results, but it also opens up new avenues for further research.

Prevalence and Diagnosis

A survey conducted in the United Kingdom in 2023 found that misophonia affects 18.4% of the adult population. To obtain a representative sample, researchers used an algorithm that considered gender, age, and ethnicity of respondents. Participants answered questions about sounds that triggered negative emotions and described their reactions.

The results showed that people with misophonia often experience anger and panic in response to irritating sounds. They reported a sense of hopelessness and an inability to escape unpleasant noises. Additionally, these individuals are more sensitive to sounds that most people barely notice, such as breathing or swallowing.

Psychological Profile

Psychologists from the University of Oxford note that misophonia is more than just irritation from unpleasant sounds. People with this condition experience a distinct emotional response that can interfere with social life and work. Meanwhile, less than 14% of respondents had previously heard of the diagnosis, indicating a low level of public awareness.

Research highlights that people with misophonia more frequently exhibit traits of anxiety, a tendency toward internal distress, and difficulty shifting attention. This underscores a link between misophonia and certain personality characteristics.

Impact on daily life

Misophonia can seriously complicate daily life, leading from irritation to panic attacks, from feelings of guilt to social isolation. For many, ordinary household sounds become a source of stress that is hard to control. Scientists believe that understanding the genetic and psychological foundations of this condition will help develop more effective support and treatment methods.

If you weren’t aware, misophonia is a relatively new concept in psychology referring to heightened sensitivity to specific sounds. The term was introduced in the early 21st century and has been the subject of active research by scientists worldwide. In recent years, interest in the issue has grown, as more people encounter this phenomenon in their daily lives. Studies suggest that misophonia may be related to brain function and genetic factors. Leading universities in Europe and the US continue to search for effective methods of diagnosis and treatment for this condition.

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